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A multiwell applicator for conformal brachytherapy of superficial skin tumors: A simulation study

TitleA multiwell applicator for conformal brachytherapy of superficial skin tumors: A simulation study
Publication TypeJournal Article
Year of Publication2019
AuthorsA. Pashazadeh, M. Robatjazi, N. J. Castro, and M. Friebe
JournalSkin Res. Technol.
Date PublishedDEC 27
Type of ArticleArticle; Early Access
ISSN0909-752X
Keywords3D printing technology, beta particles, beta-emitting isotopes, brachytherapy, Monte Carlo methods, skin tumor, Y-90
Abstract

Background Brachytherapy of thin skin tumors using beta particles can protect underlying sensitive structures such as the bone because of the rapid dose falloff of this type of radiation in tissue. The current work describes a skin brachytherapy applicator, based on beta radiation, that can provide the needed cell-killing radiation dose matched to the shape of individual skin tumors. Materials and methods The applicator and its template were fabricated using 3D printing technology. Any clinically approved beta-emitting isotope in the form of a radioactive gel could theoretically be used in this applicator. Monte Carlo simulations were employed to study the capability of the applicator in conforming dose distribution based on the shape of the tumor. Dose profile in the shallow depth, transverse dose profiles at different depths, and the percent depth dose from this applicator were calculated. The radioisotope of choice for our calculations was Yttrium-90 (Y-90). Results Using the proposed applicator, it is possible to create a desired dose profile matching the tumor surface shape. Conclusion The short-range of the beta radiation, together with the dose conforming capability of the applicator, may lead to minimal interactions with the healthy tissue around the skin lesion.

DOI10.1111/srt.12826