Graphene in its pristine form has transformed our understanding of 2D electron systems leading to fundamental discoveries and to the promise of important applications. I will discuss new and surprising phenomena that emerge when the perfect honeycomb lattice of graphene is disrupted. In particular I will focus on the effects of single atom vacancies on graphene's electronic and magnetic properties as revealed by scanning tunneling microscopy and spectroscopy. These include charging the vacancy site into the supercritical regime where atomic collapse leads to the formation of an artificial atom, and electrostatically controlled Kondo screening of the vacancy magnetic moment.
 J.Mao, Y.Jiang, D. Moldovan, G. Li, K. Watanabe, T. Taniguchi, M. R. Masir, F.M. Peeters, E.Y. Andrei, Tunable Artificial Atom at a Supercritically Charged Vacancy in Graphene, Nature Physics 2016, doi:10.1038/nphys3665